Interesting outcome... the natural stuff doesn't seem to work as well assuming everything else equal.

https://www.sciencemag.org/news/2021/06/what-went-wrong-curevac-s-highly-anticipated-new-mrna-vaccine-covid-19

What went wrong with CureVac’s highly anticipated new mRNA vaccine for COVID-19?

By Jon CohenJun. 18, 2021 , 9:10 AM

...

CureVac’s vaccine used an unmodified form of mRNA. When natural mRNA is injected into the body, it triggers the production of interferons, signaling molecules that can rev up the immune system. CureVac touted that as an advantage of its formulation. But Weissman notes interferons can also block the generation of T helper cells that, in turn, direct B cells to make antibodies.

Pfizer and BioNTech and Moderna, in contrast, chemically altered the uracils, one of the four nucleotides that make up RNA, in their spike-encoding sequences. Weissman’s group had shown in 2018 that uracil-modified mRNA triggered potent neutralizing antibodies and other protective immune responses in animal models. He notes that a BioNTech study comparing modified and natural mRNA vaccines also found that the modifications boosted the antibody response.

FDA News Release
Coronavirus (COVID-19) Update: June 25, 2021

For Immediate Release:
June 25, 2021

The U.S. Food and Drug Administration (FDA) continued to take action in the ongoing response to the COVID-19 pandemic:

Today, the FDA is announcing revisions to the patient and provider fact sheets for the Moderna and Pfizer-BioNTech COVID-19 vaccines regarding the suggested increased risks of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the tissue surrounding the heart) following vaccination. For each vaccine, the Fact Sheet for Healthcare Providers Administering Vaccine (Vaccination Providers) has been revised to include a warning about myocarditis and pericarditis and the Fact Sheet for Recipients and Caregivers has been revised to include information about myocarditis and pericarditis. This update follows an extensive review of information and the discussion by CDC’s Advisory Committee on Immunization Practices meeting on Wednesday. The data presented at this meeting reinforced the FDA’s decision to revise the fact sheets and further informed the specific revisions. The warning in the Fact Sheets for Healthcare Providers Administering Vaccines notes that reports of adverse events suggest increased risks of myocarditis and pericarditis, particularly following the second dose and with onset of symptoms within a few days after vaccination. Additionally, the Fact Sheets for Recipients and Caregivers for these vaccines note that vaccine recipients should seek medical attention right away if they have chest pain, shortness of breath, or feelings of having a fast-beating, fluttering, or pounding heart after vaccination. The FDA and CDC are monitoring the reports, collecting more information, and will follow-up to assess longer-term outcomes over several months.

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The Health Ministry says that in the past month, the Pfizer vaccine’s effectiveness in preventing symptomatic COVID-19 has dropped by some 30% to 64%.

It notes the drop in effectiveness has come amid the spread of the Delta variant.

The ministry adds that the vaccine’s effectiveness at preventing serious illness is at 93%.

https://www.timesofisrael.com/liveblog_entry/health-ministry-vaccine-down-to-64-effectiveness-in-averting-symptomatic-covid/