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Banal question about blocking email domains

My hotmail account allows blocking of domain names. This has worked well until recently. Am I wasting my time blocking email domains that "appear" to be randomly generated? Is this what's happening? Or, how can I block domains that begin with "mdm", "dqmx", etc?

I'm unable to cut and paste the domains in my block list, so I wrote a few down that illustrate the randomness of the domain names:

mxdq06.net

mdm01.org
mdm02.org
mdm03.org
mdm45.org
mdm46.org
mdm47.org

dqmx02.biz
dqmx02.org
dqmx02.com
dqmx02.net

Strange how the spam has picked up in the last week.

TIA,
Bob

It's probably a waste of time, as they're probably not valid domains or they're forged.