Very helpful. You realize all these vaccines were developed under the previous administration, right?

Yes
The only administration in History to have a working Pharma Lab in the basement of the White House
Between tweets, Don would often be found, in the lab, making doses of the tRump Vax

No doses, 2 x and poof...cured

Jonas Salk Don Trump

Heros

Knock off the condescension. Science IS questioning. Denying questioning is cult territory. Which side are you on?

That’s a pretty significant change in guidance and given the ridiculous logistics of shipping it at minus 94, something they should have looked at earlier. Did so,etching change or did they just not get around to it. Given the extreme logistics that were needed to keep it at those temps, I would have thought this would have been a priority.

It is quite clear the second dose is a booster. My guess is what they are REALLY saying is that the first does is *good enough* that as a society it’s better to get more people one dose, than half of us two doses. Also an interesting question. ...or did something change?

Jesus Christ zig, can't you keep politics out of anything? GTFOOH

There's no reason for this to end up in PARF but your jackassery is going to get it moved there.

I came across this article this morning. I thought it was an interesting take.
https://www.msn.com/en-us/health/medical/a-johns-hopkins-professor-predicts-the-us-will-reach-herd-immunity-by-april-but-many-experts-arent-so-optimistic/ar-BB1dRhJZ?li=BBnb7Kz

No problem. The road to success is paved with flat squirrels who couldn’t make up their mind.

Being under 65 and not yet eligible for the shot...why wouldn’t a person assess the options?

The road to success is paved with squirrels who weren’t concerned about what was coming.

All the more reason we need some more consistent information to decide..

..at this point I dont think anyone has the option of one vaccine vs. the others. It is my understanding that the two dose Phizer has had a higher effective rate against some of the variants and at this point would be my "choice" if I got one, but I'd like to understand more...

It makes logical sense on some level. Given the number of asymptomatic cases out there its very possible that more people were infected than we thought, and simply didn't go out and get tested. In fact we've been reading for months that the infection rates were much higher than we know... (Usually some media outlet trying to pronounce doom)

...but then it begs the question as to whether these folks developed an an immunity and how long it will last. Certainly not all will - maybe only a few. I've seen data that suggests an asymptomatic case may not bring immunity.

It’s frustrating how unreliable every bit of information is regarding this entire fiasco. As such, I’m struggling to assume the vaccine info is any better. And now with significant changes only weeks later. As you say above....you’ve seen data that suggests an asymptomatic case may not...

Nothing remotely conclusive. Heck...has there been data to confirm the immunity from the vaccine will last any longer?

I doubt we’ll have any definitives in situations like this. Especially when the media focuses on fringe cases and supposition to generate interest.

The UK (Astro Zeneca) and now Pfizer have been back checking the data from the vaccine studies and is finding that a single dose is "good enough". Now we can double the number of people vaccinated with the same infrastructure. This is good news.

On the temperatures, Pfizer was being very cautious. And they have had a few months to work on the effectiveness with less severe refrigeration. And note, the "normal freezer" temps are only allowed for storage for two weeks. You have to keep it at -94F if you want to keep it stored for multiple months or transport.

Pfizer I believe also has a shorter life in the bottle once warmed up to injection temps.

Texas Center for Drug Development is running three vaccine studies in our area: Pfizer, Moderna and Novavax. I was there yesterday getting my second "real" Moderna injection. I chatted with one of the nurses and the Novavax study is done. They are compiling the data and will be doing the FDA submittal soon.

Even after the submittal, we're still in the trial. They take blood and see how the antibodies develop and then track overtime the loss. I signed up for the Moderna Booster trial as well. We will see when that comes around.

J&J is days away from approval. That will add a HUGE amount of vaccine to the USA and the world. J&J says they can supply a billion doses this year. Maybe not as effective as the new guys. But better to get good vaccines out than wait for the others to produce.

Agree. I’m interested in the J&J iteration. Developed for single dose using a similar technology to other vaccines (HIV and tuberculosis). And...this being a multi-billion dollar business, one has to wonder about Pfizer’s motives to also become approved for single use with J&J’s drug on the horizon.

IIRC Moderna and Pfizer showed high enough efficacy to be used as a single dose but because trials were done using a two dose regimen, that's what they had to seek authorization for. There was talk back in January about Moderna possibly seeking authorization to go to one dose. The FDA shut that down.

https://www.fda.gov/news-events/press-announcements/fda-statement-following-authorized-dosing-schedules-covid-19-vaccines

"Until vaccine manufacturers have data and science supporting a change, we continue to strongly recommend that health care providers follow the FDA-authorized dosing schedule for each COVID-19 vaccine."

Interesting topic, not sure how many here work in healthcare. Both my wife and I work in healthcare, she in patient care in radiology me in sales radiology/surgery. I can back up the COVID numbers falling off a cliff at least locally to us. I think the public at large misunderstands FDA review/approval protocols which by and large unless you are really into that kind of stuff who cares.
It makes sense that both Pfizer and Moderna went ultra conservative in testing and what data was submitted for review, keep in mid both companies had a ton at stake with what in the business is called at risk manufacturing (doses ready to go into arms as soon as given the green light). You want that to go right or its untold millions down the tubes. The manufacture I sell equipment used in surgery and many others use at risk manufacturing, then as more data is compiled product refinements are made. These sometimes result in the need to resubmit data to FDA for approval sometimes not. This at risk manufacturing had a huge role in how quickly this vaccine was produced.

There is no HIV vaccine.

What are adenovirus-based vaccines?
To date, several adenovirus-based vaccines are in clinical and pre-clinical trials. Vaccines developed against HIV, Ebola virus, influenza virus, Mycobacterium tuberculosis, and Plasmodium falciparum are currently under human clinical trials. Moreover, there are vaccines under preclinical trials developed against rabies virus, dengue virus, and middle east respiratory syndrome coronavirus.

Even if they get approved I wouldn't take them because of unknown long term consequences...

Save your trolling for PARF. :rolleyes:

Nothing about the statement is parf. You can use that as a concern though I can't?