The more scenic route from So Cal would definitely be the 395 north through Reno!
Try Benton Crossing Road just north of Lake Crowley, which is north of Bishop.
Take it all the way around to the 120 north, that will lead you to the S.E. end of Mono Lake and back to the 395 by Lee Vining. It is worth the effort, and a Spectacular drive!!! Good 2 lane paved road all the way.
Also Tioga Pass that leads to the eastern entrance of Yosemite. The June Lake Loop (hwy 158) is equally as beautiful. It will make you think you were driving through the Swiss Alps! Also some nice places to stay overnight. Virginia Lakes is a nice little detour as well... The 395 north of Lee Vining through Bridgeport and north to Reno is probably the prettiest drive on the 395!
I often drive this route to visit a good friend of mine in Reno. I usually take different side route's off of the 395 every time, and am always pleasantly surprised!
Last time, I ventured out the 168 outside of Big Pine and up to the Ancient Bristlecone Forest. Altitude went from 3500' to almost 10000' in a matter of 15 miles. Spectacular view overlooking Bishop.
hwy 120 southbound from Mono Lake
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looking southeast at the White Mountain Range close to Benton Crossing
This was my first time on the 120. Looking at the map, I had always just figured this area was a bunch of sand... Boy was I wrong!
more pics to follow...