Looking at the photo... There's a lot going on there.
I've seen it happen first hand. There was one lady who when I met her was an absolute babe. She was 37 at the time and looked like she was in her 20s.
Fast forward to 44...
She's a hopeless alcoholic and now has Coeliac's disease.
Coeliac disease - Wikipedia, the free encyclopedia
I still talk to her but she refuses to see me in real life because of the way she looks.
Absolutely tragic...