Hydroxycholorquine... didn't know this was still a thing?

[cabmandone]

Doing my morning surf on MSN, I see this article
https://www.msn.com/en-us/news/world/india-distributed-over-100-million-hcq-tablets-for-covid-19/ar-BB1dnvav?li=BBnba9O

Don't know why it was there.. haven't searched for anything HCQ related in at least 6 months and have cleared cache and browser history several times. So naturally after reading it, I have to see what was going on.

https://www.medrxiv.org/content/10.1101/2020.06.09.20116806v3.full.pdf

"In the HCQ group 4 out of 54 participants were tested to be COVID19 positive, whereas, in the control group 20 out of 52 participants were found to be COVID19 positive. Distribution of HCQ takers and controls across outcome of COVID19 test in univariate analysis indicated the association of risk (Relative Risk = 0.193; 95% CI = 0.071-0.526; p = 0.001) of SARS-CoV-2 infection with lack of pre-exposure HCQ prophylaxis. In this study, it was seen that taking preexposure HCQ prophylaxis was associated with an 80.7% reduction in the risk of acquiring a SARS-CoV-2 infection."

I had no idea there was anything like this going on. HCQ was pretty much written off back in July/August from what I can recall. Studies were showing that it had no benefit in treatment and one (I think) showed no benefit in prevention. The study linked above was extremely small.

Interesting stuff.

[WPOZZZ]

I still have a supply of HCQ.

[kach22i]

Originally Posted by WPOZZZ

I still have a supply of HCQ.

Are you trying to prevent or treat malaria?

Good for 2-3 years of shelf life, right?

Originally Posted by cabmando

I had no idea there was anything like this going on.

Science, always at work, hey?

[Chocaholic]

Originally Posted by cabmando

Doing my morning surf on MSN, I see this article
https://www.msn.com/en-us/news/world/india-distributed-over-100-million-hcq-tablets-for-covid-19/ar-BB1dnvav?li=BBnba9O

Don't know why it was there.. haven't searched for anything HCQ related in at least 6 months and have cleared cache and browser history several times. So naturally after reading it, I have to see what was going on.

https://www.medrxiv.org/content/10.1101/2020.06.09.20116806v3.full.pdf

"In the HCQ group 4 out of 54 participants were tested to be COVID19 positive, whereas, in the control group 20 out of 52 participants were found to be COVID19 positive. Distribution of HCQ takers and controls across outcome of COVID19 test in univariate analysis indicated the association of risk (Relative Risk = 0.193; 95% CI = 0.071-0.526; p = 0.001) of SARS-CoV-2 infection with lack of pre-exposure HCQ prophylaxis. In this study, it was seen that taking preexposure HCQ prophylaxis was associated with an 80.7% reduction in the risk of acquiring a SARS-CoV-2 infection."

I had no idea there was anything like this going on. HCQ was pretty much written off back in July/August from what I can recall. Studies were showing that it had no benefit in treatment and one (I think) showed no benefit in prevention. The study linked above was extremely small.

Interesting stuff.

It almost seems there is a concerted effort to thwart any benefits of readily available, cheap drugs. HCQ and Ivermectin both have shown reasonable, albeit anecdotal evidence of efficacy. HCQ was touted by Trump...so, no way the media would support it even if it cured cancer.

Hard to know where reality lies even still. Because this virus was so politicized by the left...and helped them win an election last Nov, many have no faith in the honesty or reliability of COVID related information. I heard yesterday, indirectly, that there have been 24 deaths attributed to the vaccine. Don’t know if true but I know that many of us completely distrust the media to report the real news.

Edit: Uh oh...didn’t realize this wasn’t in PARF. My apologies for sharing my honest opinion as it may get this punted next door.

[cabmandone]

What got me looking was that it was an article about using it as a preventative. Then I looked at India's infection and death numbers and the fact that they have about 1 billion more people than we do but have about 1/2 the cases and 1/3 the deaths we do.

[kach22i]

Originally Posted by Chocaholic

It almost seems there is a concerted effort to thwart any benefits of readily available, cheap drugs............

That's just your paranoia talking, and there are drugs to treat that I'm sure.

So this study is roughly 40/60 with a 60 percent chance of someone getting Covid-19 while talking this drug and it's Trump was right all over again?

Comedy gold Jerry.


That's gold, Jerry! Gold!
https://www.youtube.com/watch?v=j0qm0KUPeD8




Meanwhile masks cut down your risks by even a greater amount, but bad, right?

July 6, 2020
Your Mask Cuts Own Risk by 65 Percent
https://www.ucdavis.edu/coronavirus/news/your-mask-cuts-own-risk-65-percent/

Scientific evidence is clear: Social distancing and wearing masks help prevent people from spreading COVID-19, and masks also protect those who wear them, two UC Davis Health experts said on UC Davis LIVE: COVID-19.

So in this alternate reality; an real estate mogul turned entertainer turned politician is now a scientific health expert, and the real scientists and health experts are the politicians.

Got it.

How long does it take to sober up verses sober up while still drinking?

Stop drinking, it's the only way to sober up.

[Chocaholic]

Originally Posted by cabmando

What got me looking was that it was an article about using it as a preventative. Then I looked at India's infection and death numbers and the fact that they have about 1 billion more people than we do but have about 1/2 the cases and 1/3 the deaths we do.

And abject poverty on a scale we could not imagine. Interesting.

[cabmandone]

Originally Posted by kach22i

That's just your paranoia talking, and there are drugs to treat that I'm sure.

So this study is 40/60 with a 60 percent chance of someone getting Covid-19 while talking this drug and it's Trump was right all over again?

Comedy gold Jerry.


Meanwhile masks cut down your risks by even a greater amount, but bad, right?

Your Mask Cuts Own Risk by 65 Percent
https://www.ucdavis.edu/coronavirus/news/your-mask-cuts-own-risk-65-percent/

"it was seen that taking preexposure HCQ prophylaxis was associated with an 80.7% reduction in the risk of acquiring a SARS-CoV-2 infection"

[cabmandone]

Of the 54 people taking Hcq as preventative, 4 were infected... of the 52 not taking, 20 were infected. That seems pretty big but it was a small study.

[cabmandone]

Originally Posted by Chocaholic

And abject poverty on a scale we could not imagine. Interesting.

Admittedly, I have not looked into how India handled the outbreak. I don't know if they had lockdowns or what actions they took. I do know from reading something about the HCQ use that testing and contact tracing have been a big part of their response.

[Sooner or later]

Their cases are lower because they test far less. The US at about 7x the India level per capita rate

Their deaths are far lower since they have far fewer hospital beds and most deaths don't get verified or reported. The US has 28 beds per 10,000, India has 5. Poor people die at home.

I am sure there are other metrics that create the discrepancy. Probably number of doctors being another.

[kach22i]

Originally Posted by cabmando

"it was seen that taking preexposure HCQ prophylaxis was associated with an 80.7% reduction in the risk of acquiring a SARS-CoV-2 infection"

If you can show me the math used to arrive at that number, I might be persuaded that you actually understand it's context.

Yes, big impressive number, but does it really mean?

It means exactly what I posted FYI, 40/60 approximately, and almost the same as social distancing plus wearing a mask.

You like studies?

This is a large one and over time, published just a few months ago.


Published:November 05, 2020
Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30378-7/fulltext

Summary
Background
Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro, but clinical studies found no evidence of reduced mortality when treating patients with COVID-19. We aimed to evaluate the effectiveness of hydroxychloroquine for prevention of COVID-19 mortality, as opposed to treatment for the disease.

If you already have Covid-19 then Hydroxychloroquine probably isn't going to help, and not going to help prevent the spread of it on to others like a mask and social distancing does.

Masks and social distancing still a conspiracy though, right?

[cabmandone]

Originally Posted by kach22i

If you can show me the math used to arrive at that number, I might be persuaded that you actually understand it's context.

Yes, big impressive number, but does it really mean?

It means exactly what I posted FYI, 40/60 approximately, and almost the same as social distancing plus wearing a mask.

You like studies?

This is a large one and over time, published just a few months ago.


Published:November 05, 2020
Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30378-7/fulltext


If you already have Covid-19 then Hydroxychloroquine probably isn't going to help, and not going to help prevent the spread of it on to others like a mask and social distancing does.

Masks and social distancing still a conspiracy though, right?

The best way I can think of to reply to that is

And I mean all of it. That whole comment is so incredibly ridiculous it doesn't deserve a serious reply.

[wilnj]

Originally Posted by cabmando

Admittedly, I have not looked into how India handled the outbreak. I don't know if they had lockdowns or what actions they took. I do know from reading something about the HCQ use that testing and contact tracing have been a big part of their response.

Beatings for not complying with quarantine orders might have had a part in it.

[dad911]

Originally Posted by kach22i

That's just your paranoia talking, and there are drugs to treat that I'm sure.

So this study is roughly 40/60 with a 60 percent chance of someone getting Covid-19 while talking this drug and it's Trump was right all over again?
.......

How long does it take to sober up verses sober up while still drinking?

Stop drinking, it's the only way to sober up.

I won't stoop to your level of snark, and again wonder why you have not been banned, but getting past that, can you explain how you get 40/60 or 60% from these numbers?

4 out of 54 participants were tested to be COVID19 positive, whereas, in the control group 20 out of 52 participants

4/54 is 7.4%
20/52 is 38.5%

[cabmandone]

Originally Posted by wilnj

Beatings for not complying with quarantine orders might have had a part in it.

Like I said, haven't really looked into what they're doing. They could be tossing folks in an incinerator for all I know. I don't know if they've done lockdowns. Or how drastic they've gotten with quarantine. I just found the use of Hcq as a preventative to be interesting. I knew that as treatment for those who already had COVID, it didn't show any real benefit.

[dad911]

Originally Posted by kach22i

If you can show me the math used to arrive at that number, I might be persuaded that you actually understand it's context.

.....blah blah blah......

reduced from 20 to 4.

20-4 is 16 (16 less)

16/20 = .8 (x100) = 80% (80% less, or an 80% reduction)

Lets make this simple.

If you have 20 apples, and 16 are stolen, that's an 80% reduction in the amount of apples you have. You have 4 left, or 20% of the original.

4/20 = .2 (x100) = 20%

[LWJ]

So tell me why Oklahoma is unable to use or sell their stockpile if it is so great?

[cabmandone]

Originally Posted by LWJ

So tell me why Oklahoma is unable to use or sell their stockpile if it is so great?

Don't know. I'm not offering an opinion on whether it works or not. But Oklahoma could be in a pickle because it's not supposed to be used in treatment of Covid in the USA.

https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-revokes-emergency-use-authorization-chloroquine-and

I don't know how many studies in the USA looked at Hcq for preventing infection.

[kach22i]

Originally Posted by dad911

20/52 is 38.5%

I asked you to show how the 80% improvement number was arrived at, and you failed.

Now about the numbers I posted:

38.5% = approx 40%

40 + 60 = 100

40/60 ratio

You can round up further and just call it 50/50 for argument's sake.

Take this malaria drug and have a 50/50 chance of contracting Covid-19 once exposed.

Oh and have a 3-20% (approx) chance of some side affect such as migraine headaches and or skin rashes.

50/50

I have better odds at Russian Roulette, WTF.