How Oxycontin Took Over

[Arizona_928]

Originally Posted by Tobra

You can very easily kill someone putting them through opioid withdrawal.

Restrict the hell out of opioids, and give away Ambien and psychotropic drugs like they are GD Tic Tacs. That totally makes sense, if you are freakin' moron.

Snip

That was the most interesting aspect talking to guys that went through that game. Anyone that takes 30mg x 3 daily..... Yeah you're gonna get hooked. Then cold turkey one day bc well politics. One will switch to heroin, and since heroin is super expensive now. You switch to cartel knock off perc 30's doped w/fentanyl... Throw in the fact that they wholesale via the cartel at a dollar a pill.... Hell a lot cheaper than big Pharma prices...

DEA. Beautiful organization...

[Arizona_928]

1964....

[pavulon]

Substituting LSD for opiates as a strategy for pain control is a great plan if you want to go out of business while making national news.

Ketamine (dissociative effects comparable to LSD) has its place but is not a great plan A, B and C unless the situation is extremely dire and then only until it improves enough to give other meds including opiates.

There are efforts toward establishing opiate-free environments but the back-up plan for pain control in those places is generally opiates because they are reliable.

[flatbutt]

Originally Posted by unclebilly

I have some OxyContin from my knee reconstruction. I took 2-3 pills and then switched to Percocet which is less ‘torquey’ and then wiened myself off of that the next day.

I’ve taken the Percocet one or 2 times since but that’s it.

I probably have 50-60 pills of these and they will find their way into my backcountry first aid kit.

I really don’t want them in my house but know they could be useful for pain relief in the event of a backcountry injury.

Billy, if you're going to keep those please check the expiration dating. I personally keep mine cold, but I live alone.

[Bob Kontak]

Originally Posted by Tobra

You can very easily kill someone putting them through opioid withdrawal.

Pretty sure that applies to benzodiazepines (e.g., Xanax) and alcohol, not opioids.

However, they want to die.

[Tobra]

You are correct about benzos and booze, also true of opioids and booze


Pretty easy for someone to have a heart attack going through opioid withdrawal. One of the reasons you don't let your patients go through it on purpose.

https://pubmed.ncbi.nlm.nih.gov/25024850/

[Arizona_928]

Originally Posted by pavulon

Substituting LSD for opiates as a strategy for pain control is a great plan if you want to go out of business while making national news.

Ketamine (dissociative effects comparable to LSD) has its place but is not a great plan A, B and C unless the situation is extremely dire and then only until it improves enough to give other meds including opiates.

There are efforts toward establishing opiate-free environments but the back-up plan for pain control in those places is generally opiates because they are reliable.

Little more than just a substitute.

Think receptors and big picture....

[Bob Kontak]

Originally Posted by Tobra

You are correct about benzos and booze, also true of opioids and booze


Pretty easy for someone to have a heart attack going through opioid withdrawal. One of the reasons you don't let your patients go through it on purpose.

https://pubmed.ncbi.nlm.nih.gov/25024850/

I learned that in my OVI long weekend class in lieu of incarceration. lol

[pavulon]

Originally Posted by Arizona_928

Little more than just a substitute.

Think receptors and big picture....

Please do educate everyone.

[wdfifteen]

Originally Posted by matthewb0051

Message boards and forums all over the internet describe Tramadol as the spawn of Satan and most people's experience with it are horrible. It is now a controlled substance but still favored by some docs simply because it isn't Oxy or Vicodin or similar.

It may be favored by some docs because it works if you use it right. I take one most mornings - about 5 days out of the week.
When I tried Vicodin it made me want to lay on the sofa and do nothing all day. I wasn't in pain, but I wasn't getting anything done. The thing was, if I just laid on the sofa I wasn't in pain anyway, so I didn't need a drug if that was my goal.
My back and hip pain is excruciating in the morning and taking a Tramadol helps me get through my stretches and strengthening exercises and my walk. Before I started using it I couldn't walk 200 yards and I was getting worse. Now I'm walking 2 1/2 miles a day plus half an hour of stretches and strengthening exercises. After I get over the morning hump I'm good for hours. As my doc said, "Motion is medicine" and a Tramadol lets me get the daily motion going.
Of course if you are using it to help relieve the cramps from sitting on the sofa all day, it's not your long-time solution.

[Tobra]

Originally Posted by Arizona_928

Little more than just a substitute.

Think receptors and big picture....

As if you could tell that guy anything about this subject

[jcwade]

I had a knee replacement several years ago.
I was given Hydrocodone and used it liberally, until I had a reaction and felt I was going to die.
My wife was out of the country, and I felt so bad that I contemplated calling an ambulance.
But I got over it and just stopped taking them that day.

It is good used properly, under supervision, as all drugs are.
But the opportunity for abuse is so high I can see how people get sucked into it and ruin their lives.

[Arizona_928]

I like oxytocin....

In the barracks i had a **** bag roomie. ps refused to let me change rooms. Anyways. My roomie had his acl done. Con leave denied.
So he's taking his hydrocodone and crushing it in 10 dollar bills and snorts lines right on that skillcraft desk they all have. Next script he gets oxytocin. The pharmaceutical company changes the binder so they don't crush but smear into a waxy residue... it was a sign of relief until i got out of that room.....

[Arizona_928]

Originally Posted by Tobra

As if you could tell that guy anything about this subject

I'm a chemie guy but theory of neuro isn't rocket science.

[pavulon]

Originally Posted by Tobra

As if you could tell that guy anything about this subject

If you have something to say to me, being an indirect, 5th grade girl doesn’t work.

[Arizona_928]

Whaaaa, "opiate" receptors are different than 5ht** receptors?....

/s


Find a copy of that journal on sci hub and lmk if you have any questions on the "dissociative"...

[pavulon]

Originally Posted by Arizona_928

Whaaaa, "opiate" receptors are different than 5ht** receptors?....

/s


Find a copy of that journal on sci hub and lmk if you have any questions on the "dissociative"...

This isn't PARF and is not a debate or some other cryptic BS. Try to maintain that perspective.

[Geneman]

One of the absolute BIGGEST failures of biomedical research for the last 30-40 years is the total inability to come up with a non narcotic solution to chronic ( and acute pain) that is non addictive and has none of the GI and CNS side effects of narcotics,. Compared to our huge advances in many diseases, this is an abject failure both of focus and expertise to take it on... ( notwithstanding political will) The major pain signal transduction pathways, receptors, nerve efferent and afferents have been well known for 50 years! Big pharma is to blame also as they would rather one of their most reliable cash cows to not go away.... its astounding

[Arizona_928]

Originally Posted by pavulon

This isn't PARF and is not a debate or some other cryptic BS. Try to maintain that perspective.

Don't be a rube....
There's nothing cryptic in that response...

Now.
Fly fly fly


Fly fly fly

[Arizona_928]

So for some on ppot that still have some firing dendrites.
Sci hub is an open source doi search engine for scientific journals.