Hard way to earn £2,000, Victims tearing at shirts

[kach22i]

Victims tearing at shirts
http://www.thesun.co.uk/article/0,,2-2006120434,00.html

[Flatbutt1]

Anybody still want to buy their medicines from outside of the US?

Having said that, it WAS an experimental trial. The risks are real, thats why the volunteers are paid and limited in number. Someday we'll find a better way to test these drugs. I hope.

[kach22i]

Originally posted by Flatbutt1
Anybody still want to buy their medicines from outside of the US?

Having said that, it WAS an experimental trial. The risks are real, thats why the volunteers are paid and limited in number. Someday we'll find a better way to test these drugs. I hope.

Read the article, test were done for an American company.

Oh wait, why am I laughing?

[techweenie]

Why cant they test this stuff on pedophiles?

[wludavid]

can someone post the text? My firewall is blocking it.

[kach22i]

By NICK PARKER,
EMMA MORTON and
JACQUI THORNTON
A VOLUNTEER who escaped the drug test disaster told last night how he saw six healthy young men turn into wailing wrecks within minutes.

Human guinea pig Raste Khan — who did not know he had been given a harmless placebo in the test — said it was like a horror film unfolding before his eyes.

The 23-year-old TV technician added:

The test ward turned into a living hell minutes after we were injected. The men went down like dominoes.

First they began tearing their shirts off complaining of fever, then some screamed out that their heads felt like they were about to explode.

After that they started fainting, vomiting and writhing around in their beds.

It was terrifying because I kept expecting it to happen to me at any moment. But I felt fine and didn’t know why.

An Asian guy next to me started screaming and his breathing went haywire as though he was having a terrible panic attack.

They put an oxygen mask on him but he kept tearing it off, shouting ‘Doctor, doctor, please help me!’ He started convulsing, shouting that he was getting shooting pains in his back.

Last night two of the victims were still fighting for life in Northwick Park Hospital, North West London, while the other four were listed as “seriously ill”.

Another victim, a 28-year-old Asian man, was said to “look like The Elephant Man”.

A frantic global race to find a “cure” was launched yesterday.

The patients’ blood was being filtered every HOUR in a bid to remove any possible toxins.

And homicide cops from Scotland Yard were drafted in to probe whether any negligence or deliberate tampering with the drugs was involved.

The six affected were among eight volunteers taking part in clinical trials for the American Parexel research company.

Two were given placebos for comparison purposes.

The others were injected with a new drug called TGN 1412, being tested for German firm TeGenero.

It is an anti-inflammatory agent makers hoped would become a lucrative treatment for rheumatism, leukaemia and multiple sclerosis.

The drug has passed tests on animals but Monday’s session at the hospital was the first time it had been tried on humans.

The trial group was made up of one Englishman — Ryan — four Asian Brits, two Australians and a South African.

They were each being paid £2,000 plus £30 a time for 11 follow-up checks.

Raste, of Roehampton, South West London, said: “We all turned up on Sunday and slept on what looked like a private ward before being given the drugs in the morning. We had needles inserted in both arms with valve devices so they could inject drugs and take blood for tests.”

Raste said four men in smart suits, who he assumed were from the drug company, mingled with nurses and kept tabs on the test.

But they “made themselves scarce” as it all went wrong and the victims were rushed into intensive care.

The girlfriend of the unnamed 28-year-old, who runs a London bar, told last night how he had taken part in trials before.

And he volunteered for the one at Northwick Park, a complex which also includes St Mark’s Hospital, “to help mankind”.

Myfanwy Marshall, 35, described him as “completely gorgeous, really buoyant, oozing with charm and really muscly.” But last night he had changed beyond recognition.

The girlfriend, who saw him in hospital, said: “He was completely lifeless, like a shell.

“He can’t even move his eyelids. This machine is pumping out his lungs and his face is puffed out like The Elephant Man. A day ago he was fine and now they are saying he could die at any moment.”

She added: “The doctors say they are in the dark because they don’t know the drug or what it can do. They don’t know what they are dealing with.”

Parexel yesterday sent blood samples from the victims to the US for urgent tests.

And TeGenero flew in 20 German doctors from its HQ in Wurzburg to see the patients.

Britain’s watchdog body the Medicines and Healthcare products Regulatory Agency sent out alerts to counterparts in Europe.

The homicide cops are liaising with health chiefs to ascertain if any crime has been committed.

A senior source said: “Should any of the volunteers die, this could become a manslaughter inquiry or — at the very worst — murder.”

TeGenero’s chief scientific officer Thomas Hanke said: “The investigation must proceed quickly into these shocking developments in the testing of a new medicine, which showed no signs of any safety problems in previous testing.”

Victims will be able to sue despite signing consent forms if medics did not act reasonably, lawyers said.
# DO YOU know any of the human guinea pigs affected? Call The Sun on 020 7782 4104, text us on 07917 576539 or email exclusive@the-sun.co.uk.

The head of trainee plumber Ryan Wilson, 21, is three times its normal size and his limbs are purple. Doctors said his chances of survival were slim.

[RallyJon]

It's got to be pretty unusual to have a drug not cause any problems during animal testing and affect humans so profoundly. In the coverage that I heard this morning, they said the docs had no idea why the people were having such problems, and they could do nothing but treat the symptoms.

Hopefully this won't make drug trials any more difficult than they are already. There are so many drugs that could save lives that aren't available. I fear that such a high profile disaster will keep even more effective safe drugs off the market as the drug companies scramble to conduct ever more rigorous trials.

Good article on the topic in The Economist a couple of weeks ago.