I have never been troubled by allergies much, so don't take a lot of benadryl. I know a lot of people do, and diphenhydramine is in a lot of stuff, as ubiquitous as acetaminophen.
Scary dementia correlation
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When the researchers examined the use of anticholinergic drugs, they found that people who used these drugs were more likely to have developed dementia as those who didn’t use them. Moreover, dementia risk increased along with the cumulative dose. Taking an anticholinergic for the equivalent of three years or more was associated with a 54% higher dementia risk than taking the same dose for three months or less.
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