Or maybe he just couldn’t hack being in jail forever. Kind of tough going from a $77M house in Manhattan w a private chef to a small cell alone for 23 hours a day. Add in the 45 year sentence ahead and most people would be looking for the ejector seat lever.
As for how he did it, I haven’t seen any reports yet but I’m sure that Drudge Report and Breitbart have already seen death photos and spoken w the prison guards.

Where there is a will, there’s a way. I have a close friend who managed to hang himself in SHU @ Cochran a few years ago, supposedly impossible to do. He wasn’t accused of anything like Epstein was, just a guy in prison, cut off from his anti-depressants.
Or maybe Hillary Clinton, that all powerful Game of Thrones type figure, had him murdered. We all know that she runs the world these days and can have anyone killed, anywhere and that the entire right wing media and LE population plus thousands of Russian trolls like the OP can’t lay a glove on her. She’s that good.