Golly trying to tweak a 40 Gig tiff file is fun using Photoshop.
Photoshop just starts to cry and will not play with a file bigger than a paltry 4 GB. So I have to chop up the giant file into bit size pieces that Photoshop can handle. I end up with 25 tiles, that I can tweak, make them look better, and then make a final image the clients will love.
What a boring part of the job. I can't even take a nap today because of it!