I've come to really dislike rubber grips on my handguns. I had them on a number of guns when I was younger, believing they offered a few advantages like a better, more consistent grip, and a bit of relief from the sting of recoil associated with some of the heavier loads used in my hunting revolvers. I've since come to realize I was wrong about all of that.
Properly shaped, hard, smooth wooden grips are, in my opinion, superior in every way. They offer every bit as consistent of a grip, and I feel they absorb heavy recoil better than rubber. They don't squirm around and twist in the hand as much, and they don't grip the hand, causing the skin to twist and stretch. I just find them far more comfortable, especially with heavy loads. The key is that they are smooth rather than checkered - I dislike checkered wood grips almost as much as I dislike rubber grips. They just chaff the hand too much, and offer no advantage in holding onto the gun.
My only exception to the above are the hard rubber grips offered on the Peacemaker. They aren't sticky and grabby like the popular soft rubber grips, behaving far more like wood grips. And, well, they are just kind of traditional and, to me, aesthetically pleasing, so I put up with them. At least on the Colts. All of my other single actions wear wood.
Colt:
Virginian Dragoon:
