[pmax]

Originally Posted by jyl

Latest trial data. 440 randomized trial underway in Brazil, with control, high dose and low dose arms. They had to halt the high dose arm because of adverse effects (increased deaths) and no indication of enough efficacy to justify the AE.

https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1

Yeah, stuff can kill you taken in excessive quantities, even water for example.

"https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1
Eligible participants were allocated to receive orally or via nasogastric tube high dose CQ (600mg CQ twice daily for 10 days or total dose 12g); or low dose CQ (450mg for 5 days, twice daily only on the first day, or total dose 2.7g). In addition, all patients received ceftriaxone and azithromycin."

Here's another study. Note the 2x difference in dosage.

https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1.full.pdf
Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients
"Patients received 200 mg of oral HCQ, three times daily, as suggested by a recent study [9]. "