[jyl]

Another observational (not randomized, not blinded) study of HCQ finds no benefit, this is a large one, 1300 patients.

There is a randomized, placebo controlled trial underway to see if HCQ has any *preventative* effect when given to healthy persons who have had recent contact with Covid infected. It is a large trial (1,000 patients planned) and has already had two interim analyses where the trial was not stopped for futility or for safety (which is a possible good sign, but still just reading tea leaves). Third interim analysis today, some possibility trial might be stopped because it is getting hard to enroll subjects (per lead investigator), if so data will be submitted for publication.

Not sure how interesting a preventative effect will be (like, who would you give drug to? HCW? relatives of sick? essential workers? how will you decide if odds of having contracted covid and then developing a severe case outweigh the potential adverse effects of HCQ? tricky.)

But still interesting.

There’s still the large treatment trials of HCQ ongoing as well.