When I first got my jacked up GMC Jimmy with huge tires it was jacked up with shocks only to add the 4 inch lift to clear the tires. It killed the rear u-joint. Fixing it required not only re-balancing the drive shaft, but added spring lifts and shocks for the increased travel, AND special axle mounts that angled the front and rear differentials to keep the increased angles from killing u-joints.
It would have been cheaper to go back to regular diameter tires, but where's the fun in that?
When the rear u-joint broke, I just pulled the drive shaft out of the transfer case and put a cap from a can of paint on the hole. Then locked out the front hubs so I could just use the front wheels since it was 4x4. Well, it just made grinding noises and didn't move. Seems it had been stuck in mud long enough the grease in the front hubs had been replaced with mud. It rusted out the springs that made the lock-out hubs work. Had to replace the hubs as well as the suspension stuff.