Remember the doctor who lost all this platelets ? That's thrombocytopenia.
https://www.the-sun.com/news/2305200/doctor-dies-36-others-develop-rare-blood-disorder-vaccines/
Just three days after he received the Pfizer vaccine, Dr. Gregory Michael, 56, of Miami Beach developed symptoms for immune thrombocytopenia, a rare blood disorder that stops the creation of platelets, which are necessary for clotting.
Luz Legaspi, 72, woke up to find bruises on her arms and legs and bleeding blisters in her mouth just a day after receiving her first dose of the Moderna vaccine.
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39 persons with a newly described syndrome characterized by thrombosis and thrombocytopenia that developed 5 to 24 days after initial vaccination with ChAdOx1 nCoV-19 (AstraZeneca), a recombinant chimpanzee adenoviral vector encoding the spike protein of SARS-CoV-2.3-5 These persons were healthy or in medically stable condition, and very few were known to have had previous thrombosis or a preexisting prothrombotic condition. Most of the patients included in these reports were women younger than 50 years of age, some of whom were receiving estrogen-replacement therapy or oral contraceptives. A remarkably high percentage of the patients had thromboses at unusual sites — specifically, cerebral venous sinus thrombosis or thrombosis in the portal, splanchnic, or hepatic veins. Other patients presented with deep venous thrombi, pulmonary emboli, or acute arterial thromboses. The median platelet counts at diagnosis were approximately 20,000 to 30,000 per cubic millimeter (range, approximately 10,000 to 110,000), but the rate of decline in platelet counts that preceded thrombosis is unknown. High levels of d-dimers and low levels of fibrinogen were common and suggest systemic activation of coagulation. Approximately 40% of the patients died, some from ischemic brain injury, superimposed hemorrhage, or both conditions, often after anticoagulation.
What component or components of the vaccine (adenoviral sequence, spike protein, or other component) elicit a new (or recall) response to a seemingly unrelated host protein, PF4?
NEJM