From an October 2020 article:
TAR DNA-binding protein 43 (TDP-43) aggregates are frequently observed in multiple diseases, such ALS, FTD, AD, and LATE
-Amyotrophic lateral sclerosis
-Frontotemporal dementia
-Alzheimer’s disease
-Limbic predominant age-related TDP-43 encephalopathy
So the TDP-43 is not new news but what it specifically does must be new? The article I pulled the above sentence from is not written for a layman but I can't see what it specifically does. Is it the new molecule that breaks down the TDP-43 the breakthrough?
https://www.nature.com/articles/s12276-020-00513-7