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One of the absolute BIGGEST failures of biomedical research for the last 30-40 years is the total inability to come up with a non narcotic solution to chronic ( and acute pain) that is non addictive and has none of the GI and CNS side effects of narcotics,. Compared to our huge advances in many diseases, this is an abject failure both of focus and expertise to take it on... ( notwithstanding political will) The major pain signal transduction pathways, receptors, nerve efferent and afferents have been well known for 50 years! Big pharma is to blame also as they would rather one of their most reliable cash cows to not go away.... its astounding
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