[Arizona_928]

Originally Posted by Geneman

Just published this week. A non-opioid, NON sedating pain drug. Found solely my molecular modeling of the binding cleft in receptors related to the classic opioid receptors. THERE IS HOPE!!

https://medicalxpress.com/news/2022-09-non-opioid-compounds-squelch-pain-sedation.html

https://www.science.org/doi/10.1126/science.abn7065

Have a few thoughts on that article. Computational aspect imho is smoke n mirrors. Nothing really new out of that compared to a lot of known stuff. Especially when the main skeletons are relatively the same and only modifications of functional groups. Hence pro-drugs and isomers. What's interesting is the single bonds(spinning) with the ring. If i have some time I'll compile some known structures to outline the similarities.