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I did an 18.5 hour nonstop flight from JFK to Singapore last year. There are a lot of good tips that have already been provided.
But, there is one I would highly recommend if it is possible. Upgrade your seat! On my flight to Singapore, I flew business class. It helps immensely to spend some time with your feet elevated and it provides a much more comfortable sleeping position.
I still got up often to walk around the plane and stretch my legs. When walking through the Economy section it convinced me that I made the right move to upgrade. There is no way I could have gotten comfortable in an economy seat.
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