A few references from friends who are doing this now, or have done it:
https://vagabonding.net/
https://www.jumpspeak.com/blog/how-to-vagabond
To a person, they recommend a trial period of six months to a year with a re-entry plan: don't sell the house in other words until you have enough data points pro or con.
They also council getting real budget numbers in terms of practical needs and exchange rates, including the cost of luggage (believe it or not, that is huge).
That is it from my perspective.