I made my parents real proud when I came home from my first college year 1n 1972 wearing a t-shirt with your thread title.
.
The white pill with 714 on it didn't help.
Round-up is fairly safe other than spray drift (like you mentioned). Flowers will be the first affected...they are have no resistance to Glyphosate.
Round-Up is dissipated as soon as it touched the ground...it only affects plants that are green and growing.
The other spraying, if it includes Atrazine or other restricted chemicals, are watched very closely for mis-use.
The chemicals can only be purchased by a licensed applicator with the proper testing.
They are recorded as to quantity and acres applied for each year. They are expensive and handled carefully.
Homeowners are the problem for over-application.