My (wife's daily)newest Cayenne V6 is a 2013 so I don't know whether the 2016 models are the same. I think we are just over 100k on it now and it has been very reliable. I have changed the transfer case oil twice now with Ravenol just out of caution. Other than that, I have only replaced tires and brakes and regular oil changes. Everything works as it should thus far.
My daily driver is an '08 V6 Cayenne with about 240k. When I first bought it with about 130k, I removed and had the transmission valve body rebuilt as it shifted kind of funny when I bought it. Over the 10+ years of ownership and 100k+ miles, I have done the Jimmy fix on the drive shaft bearing, replaced the valve cover due to torn internal air/oil separator, replaced an electric cooling fan, replaced the high pressure fuel pump, changed the transfer case oil a couple times, replaced brakes twice, replaced tires twice, replaced one exhaust flex pipe, and replaced the center display screen.
Interior is still very nice and everything works. Porsche build quality is pretty solid in my opinion compared to other brand SUV's.
This thing owes me nothing and I will drive it until the wheels fall off.

I am currently replacing the original shocks/struts/springs with new and a adding lift kit to go along with my new oversize all terrain tires... Going for the overland look.