With the cost and availability of R-22, it makes sense to consider a change now.
Keep in mind that many of the new refrigerants are considered to be A2L rated. A meaning non toxic, 2 meaning some flame propagation, L meaning Low (burning velocity or propagation).
Some of these systems will require some sort of refrigerant monitoring equipment and that may be factory installed or it may not.
I think that when Honeywell or Dupont lose a patent on a product, it automatically becomes a "bad" refrigerant.
I did look up the AC pro equipment listed and didn't see a manufacture type for the other quote. Make sure you know what you're getting and research the reliability of the product before accepting the quote.
A heat pump application may make sense too depending on your utility costs.