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I get cortisone shots every year or so on the top of left foot between the third and fourth toes because of a neuroma. Hurts like hell during and immediately after the shot but the pain subsides not too long after. Feet are extremely sensitive extremities but I don't think wrists are as much. My podiatrist recommends cortisone shots rather than surgery for removal of neuromas. Get the shot but remember that the relief you feel is artificial for a while until you're completely healed. This is just from personal experience.
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