They poke fun at all sides, so I don't see how the movie will affect anyone.
BTW, the lead animator for South Park went to the University of Nebraska, Kearney... the leftie indoctrination camp I attended for awhile. Trey parker and Matt Stone are both republicans, also:
http://www.foxnews.com/story/0%2C2933%2C40820%2C00.html