You can get Outlook for Exchange Server and CheckPoint makes a VPN all for the Mac.
Filemaker Pro is 100% cross-platform compatible, grew up on it and loved it, but having the opportunity to create some custom apps with Access,
VB and real SQL statements years ago, I'd have to say Access is a better product. Some of the apps we created were just amazing and I don't think FMPro could have come close at the time.
I just got the latest version of FMPro and have absolutely no idea how to use it anymore.
It used to be so intuitive, now it seems silly and "wrong," especially when architecting the table structure.