That's a funny question; neither is a good option IMO. Life is not fair, of course, but you have actually touched on a serious subject that has been studied by academics. People who possess good looks have an undeniable advantage in life, from the time they are small children. Studies show that kindergarden teachers percieve them as smarter and having other favorable traits, (whether they actually are or not), and the "extra points awarded" continues through life.
If someone is woefully deficient in some other catagory, (like your examples), the advantage of being beautiful or brilliant would be somewhat cancelled out. A more realistic scenario is someone who is average in one of the areas and exceptional in the other.
My Mom always used the example of her sister, (a great beauty when young apparently), as someone who never fully developed her other talents because it was too easy to just get by on, or be rewarded for her looks. These people can have problems later on in life when their looks inevitably fade, and their shallow mate trades them in on a newer model. Ain't life a biatch?
I'd personally take being extremely creative and resourceful, w/ a naturally positive attitude and the luck of good health to being extremely brilliant or good looking. My brother is "off the scale" brilliant, but he is also a positive person or it would all be for nought.
Being frightfully homely or stupid would suck, just be grateful for whatever you were given. If you own a Porsche and have a roof over your head, you're ahead of the game most likely.