[gr8fl4porsche]

I use Spybot and the Microsoft Beta.

Microsoft's version runs in the background and will auto check your computer based on your scheduling. Spybot only checks when you run it.

So, I have MS running and checking every night about 3am and I manually use Spybot every week or so. Both have found or prevented stuff regularly and seem to play nice together.

Also use Ad-aware every week or so - always finds something.