Stock CIS pistons offer a number of challenges. Valve to piston clearance being the major on.
In the past we have placed valve pockets in CIS pistons and the results were acceptable. (be it lower compression and only done to accommodate a customers budget).
If your project is (as most projects are) governed by budget concerns, I would look to our host for some very reasonably priced JEs and build and engine that will run on CIS, MFI, carbs or EFI and add the new induction later.
What engine configuration will run with all these intakes?
I'm not sure, what is certain is that it will be a compromise, but what engine isn't?
The key will be the cams. I would ask our resident expert John Dougherty what he would use.
https://forums.pelicanparts.com/drcamshafts.com
Perhaps a version of a S Cup cam?