[Motorhead-45]

The only thing you give up by going to the 2500 is some degree of ride quality. When unloaded the 2500 will ride worse than the 1500 but neither will ride like a Cadillac! Both trucks are physically the same size but you get bigger/better drivetrain across the board with the 2500. If towing is more than about 5% of your total driving I'd certainly opt for the 3/4 drivetrain.