[TonyG]

RarlyL8

>>>By negatives I am thinking about such things as "how do you bypass the throttles during closed-throttle events" and "is there a signifcant air flow interruption in the design needed to house these ITBs in a turbocharged application".
<<<

I'm presuming that you are refering to a CBV (compressor bypass valve).

You don't bypass the throttle bodies. You bypass the compressor and intercooler.

ITB's have nothing to do with this since the bypass is not behind the throttle plates.

The vacuum source is built into the throttle bodies (which is exactly where you get your MAP source).

It's a trivial affair...

TonyG