[M.D. Holloway]

If your thinking about aspirin (aka Acetylsalicylic Acid) than Nostatic is correct, they do undergo oxidation - like all things. You will know when your aspirin goes bad cuz it will smell like vinegar (aka Acetic acid). This is due to the aspirin oxidizing. Take a whiff of an old aspirin bottle. If it smells like vinegar then they have lost some potency.

Most all drugs have a few carbon rings and some carbon chains - few are complexes with metals but the majority are an arrangement of carbon and hydrogen atoms and maybe something else to a small degree. Carbon Hydrogen bonds are susceptible to oxidation and water vapor and heat and even light act as a very nice catalyst. That is why you are supposed to store then in a dry, cool place and why the bottles are normally dark. This is to protect them form oxidizing - when they oxidize they loose their reactivity or potency. The dosage is balanced out for peak efficiency but if it is a little less reactive (potent) than design it may be very ineffective.

BTW - 10 grains (2 tablets) of Aspirin is all you need for reducing inflammation, any more and the body just doesn’t process it