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In the mid '80's when Aspartame was approved by the FDA, it was the single most tested ever. GD Searle was still owned by the Searle brothers and they were in a major pissing contest with the long standing senator from Wisconsin that headed the appropriate committee (can't remember his name, Proxmeyer?).
The story goes that Seale and the senator had a heated meeting prior to a 1979 FDA PMA hearing in which Searle told the senator that if he blocked Aspartame again, they would move their businesses from the state. A 24' bed truck later delivered the submission to the FDA, yet the applicaton was denied.
Searle began moving businesses from Wisconsin -I soon after went to work for one of them in TX- and they began another round of testing. Some where around '85 when a tractor trailer pulled up to the FDA with the latest testing, the Wisconsin senator was not longer able to block the product and it was approved.
Is the product safe? I have no idea. That said it was tested more than anything up to that point and would still rank way up there.
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'17 Cayenne
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