My first (and only so far) is a .45 ACP. I liked it at first, but it's too big and heavy... and the ammunition isn't cheap.
But a .22 ?! C'mon, the guy wants a HANDGUN, not a firecracker. (Flame suit on.…yea, I know a well-shot .22 is better than a, blah, blah, blah)
If I were to do it over again, I'd have gone 9mm.
For crying out loud, did I just join a gun thread? Need to get out more.