My dad lived in Louisville for a while. I drove from Philly to visit him a few times.
One word of advice, when exploring the excellent backroads of rural KY, know where you're going and know when to stop. I lock my doors when driving downtown at night. And I damn well locked my doors when I came into the "village" at the end of one of those twisty Kentucky roads. Got the hell out of there before any pig squealing got started.