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On Macs for years. No trouble with Mac/PC Adobe Photoshop, GoLive, files etc.
Only two "real" problems (which turned out NOT to be MS Office-related):
1. Powerpoint: files were sometimes slightly altered - we traced it back to missing fonts as described earlier.
2. MS Word: people on PC's were sometimes unable to open some of our documents - we traced it back to the fact that these people had cheaped out and instead of buying MS Office, they had instead installed discounted school versions of MS Office on multiple machines. Never found out what the problem was. Solution was to have them buy a "real" copy of MS Office, or, for some of the real cheapies, save our documents as ".rtf" files rather than ".doc" files when these few needed to see something.
So not really software cross-platform problems, but instead human nature problems.
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