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If you build up the calves and quads too quickly, without balancing them, this may lead to a nasty case of shin-splint where it seems impossible to lift the toes up in normal walking(I've experienced this).
Take it real easy for the first six months and use the lower gears lightly on hills- cardio is best with repetition. Swiming in combination will probably help.
Too many people start a program, push it, get an injury, and then quit. Then they are injured and unmotivated.
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Meanwhile other things are still happening.
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