take 27 from orlando (or wherever is convenient) up thru ocala and then to williston, then up 27/41 thru archer, newberry, high springs (beep as you go by), then either 41 north to a short i75 run or 441 north and then up thru lake city...
Also a nice back road run from Macintosh (on 441, between Gville and ocala) up to Archer, lots of curves...
Might want to get a DeLorme Florida Atlas ... it shows all the little back roads
