Any real range of sorts should have a beginner class, intermediate, concealed carry etc. Most of the people at the range are pretty cool; what you need to watch for is the occasional individual that is lax with muzzle control (i.e. fiddling with his handgun and his barrel is aimed at your stall instead of downrange)- those folks get a polite but stern warning from me once and only once...after that you ask for them to be removed from the range.
The range near me has a variety of different handguns to rent, you might start your wife with a .22 and something that fits her hand. Good idea to learn safe practices and marksmanship first- while its cool to let her experience a .45 or .357, that can sometimes have the opposite effect of what you're after.
