6' and 175lbs -
Have put 6 - 8 weekends of 1100+ miles on mine. As long as I take a break every 100 miles or so, I can keep going. The only part that finally gets to me is the seat after that 100 miles or so. Of course I couldn't sit in any chair for more than an hour and not have to move around or get up. I had a Corbin on my last sport tourer and that didn't seem to be much better, so I will be keeping the stock seat for right now.
With only a throttle rocker, my shoulders or wrists don't bother me. I ride 250 to 350 mile rides on various weekends and arrive back at the house ready to go on another.
My only complaint - As Roloo mentioned, the thin grips. I really need to get out there and swap them out for something with a little cushion. Just lazy about it I guess. (Or too many projects.)
Right now, it is my "Do it all" bike.