[svandamme]

Windows should recognise the drive even if the bios cannot
pretty sure Windows 2000 Server can deal with volumes that size, as long as they are not the boot volume

one thing about usb drivers, power
IF the enclosure is not externally powered, and relies on usb power
you can get all sorts of states of not working, simply because the disk doesn't get enough power.... especially if the USB ports have multiple devices attached to it

so if the enclosure uses one usb cable for data, and another one for power
you'll need to make sure they are both attached to a seperate USB controller

note, having 2 ports on the pc, does not mean they are both on seperate controller, they just might be 1 controller, with an internal hub
ideally , get yourself one of those usb power thingies for charging ipods in the mains
or at least plug the 2 cables one in the front usb ports of the pc, one in the back, that way you have a better chance they are on seperate controllers