I bought my S with Suburban Peg lowering kit and removed them due to scraping the brake pedal and pegs. It's a 2000, so the bars are a little higher than the '99 from what I gather. I have done back-to-back 500 mile days with little problem (oh yeah, I'm 5'10 and have a 32" inseam) except for the stock seat. I met up with a group on the Charahala highway and rode along with an RT up and over Deals Gap. He had no problem with his pegs and was riding at the same overall pace as I was and after 6-7 track days with my S, I hang off the bike, although rather conservatively on the road. I have since upgraded the seat and remounted the Suburban Kit and a set of Rapid Dog's Barbacks. For me, the most critical factor in fatigue with the S vs. the RT is the wind buffetting. If you ride at 70mph or lower (Blue Ridge Pky. speed) then it is not much of an issue, but if you are on open road at 65 and above, the wind is brutal (for me). I plan to add a Laminar Lip to help change that. I also have a little back problem (over 50 crowd) that is not an issue with the S. The S is one bike that I don't plan to ever get rid of.