[hcariss]

Yes I have. The driving in cities is very similar to driving in Rome, out of the city its can get a bit crazy but just approach with caution and you will be fine. The toll highways are cheap and very empty, however there is some CRAZY high speed driving on some freeways, from cars and trucks and buses ...
Avoid the police, my good friend who I work with out there advises avoiding all contact with them, also when it rains Traffic Police are nowhere to be seen so traffic accidents can cause major delays.
I drove from Istanbul to the Agean, there is some lovely scenery, just like Greece (obviously) and we also went to Datca peninsula (below Marmaris) visually it was amazing, its where the Lycians lived in ancient times. We did more of the coast, and went as far as Kas which was this nice little fishing village, with pretty good diving for the med.
Not sure how long your trip is but I think your journey might take a while.
Evren who posts here is from Turkey, he seems like a very nice guy, I would PM him.
Safe travels