[Christien]

I also get spam from myself all the time. Usually it's from an old email address that I deactivated a couple years ago, because I was receiving so much spam on it (up to 100 a day!). The name and address have been "stolen" and used as the return address on spam emails. So it doesn't necessarily mean your wife's address book or email software has been compromised. Not much she can do about it now, except change her name on her outgoing emails, so that the stolen one can be blocked by her friends. For example, if her name was Catherine, change the "from" field to Cathy or something.