[Noah930]

Still, the most statistically likely etiology of your wife's symptoms is going to be carpal tunnel or cubital tunnel syndrome. Both are often common at nighttime. (Common things happen commonly.) The textbook says carpal tunnel (median nerve compression at the wrist) affects the thumb, index finger, middle finger, and half of the ring finger. Cubital tunnel syndrome (ulnar nerve compression at the elbow) affects the other half of the ring finger and the pinky (small finger). But sometimes people don't perfectly fit the textbook presentation. Some 15% of people have a Martin-Gruber anastamosis where the median and ulnar nerves connect in the palm, possibly giving some sort of cross-innervation.

See if she can differentiate which fingers bother her (get numb) more. Do they ever go numb during the day? Does she get these symptoms by turning her neck left and right or moving it around? What happens if she bends her elbows and holds them in that position for a minute? Do her hands go numb with that? What happens if she holds the backs of her hands together and flexes the wrists at a 90 degree angle with the fingers pointing at the ground? Does that recreate the symptoms? If you lightly tap on the palm side of the wrist, do the fingers tingle? If you tap at the "funny bone" does that cause the fingers to tingle? Which ones?