the economists I talk to, and
AFAIK, all say that isolationism & protectionism is bad - if we all bought Made in USA only, others would still buy elsewhere
eventually, the chasing of cheaper labor that Shaun noted will end -- as other countries develop their labor rates will rise - how long that takes I dunno
also, there will be increasing automation of high labor product manf. & design - we are not nearly done with that process
I don't know what will happen to people with a low educational level -- it seems like they will get hit hard. And, not everybody wants to or is fit to get more and more education -- of those that can or will do it, many are still not able to tolerate the sort of technical education leading to a good job (e.g. the artistic types).