I love Angelo's on Mulberry Street in Little Italy. The best Italian food I've had had! It's not too hard to get a table and not too high priced like many places in Manhatten. Also, Bubby's in Tribeca is cool. It's got a neighborhood atmosphere and is more American / comfort food with famous pies. Anyone at your hotel should be able to fill you in on the exact address.
Have fun... I'm going for some interviews in January and can't wait!
Happy Turkey Day,
Pete