I don't have any experience with Colt but was properly impressed with the Defender .45 over a Turners.
Today I visited a highly recommended (on CalGuns) shop - DAS in Solana Beach. Wow. The folks there are super cool and succeeded in muddying my pool. A month ago I was all set on the Smith & Wesson M&P 45. Then after renting the Sig P220 Combat a couple more times I was convinced it was the one. Well today I fondled the HK 45 with a custom trigger setup...dang it. I rented a USP 45 a few months back...I need to revisit that gun...to be sure.
It's only $200 more than the P220...or $750 more than the M&P... I hate having expensive taste.
Regardless, I am driving to OC tomorrow to close a PPT on a Smith & Wesson 686 for my son so I am off the table for the next 31 days.
Good luck with the Colt Talo!