If not a lot of luggage...
Mid day arrival Orange line train to downtown is fine.
That said,
As in any big city, situational awareness is key. Be alert.
There is a downtown Loyola campus and then the main campus further north.
Google up the CTA transit map.
If she's in desperation for a direct ride, pm me and depending on arrival time, I could possibly get one of my downtown "hipster" daughters to get her to her destination safely. They owe me a lifetime of favours